The Evolution of Host Specialization in the Vertebrate Gut Symbiont Lactobacillus reuteri

  title={The Evolution of Host Specialization in the Vertebrate Gut Symbiont Lactobacillus reuteri},
  author={Steven A Frese and Andrew K. Benson and Gerald W. Tannock and Diane M. Loach and Jaehyoung Kim and Min Zhang and Phaik Lyn Oh and Nicholas C. K. Heng and Prabhu B. Patil and Nathalie Juge and Donald A. Mackenzie and Bruce M. Pearson and Alla Lapidus and Eileen Dalin and Hope N Tice and Eugene Goltsman and Miriam Land and Loren Hauser and Natalia Yordanova Ivanova and Nikos C Kyrpides and Jens Walter},
  booktitle={PLoS genetics},
Recent research has provided mechanistic insight into the important contributions of the gut microbiota to vertebrate biology, but questions remain about the evolutionary processes that have shaped this symbiosis. In the present study, we showed in experiments with gnotobiotic mice that the evolution of Lactobacillus reuteri with rodents resulted in the emergence of host specialization. To identify genomic events marking adaptations to the murine host, we compared the genome of the rodent… CONTINUE READING
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