The Evolution and Variety of RFamide-Type Neuropeptides: Insights from Deuterostomian Invertebrates

@inproceedings{Elphick2014TheEA,
  title={The Evolution and Variety of RFamide-Type Neuropeptides: Insights from Deuterostomian Invertebrates},
  author={Maurice R Elphick and Olivier Mirabeau},
  booktitle={Front. Endocrinol.},
  year={2014}
}
Five families of neuropeptides that have a C-terminal RFamide motif have been identified in vertebrates: (1) gonadotropin-inhibitory hormone (GnIH), (2) neuropeptide FF (NPFF), (3) pyroglutamylated RFamide peptide (QRFP), (4) prolactin-releasing peptide (PrRP), and (5) Kisspeptin. Experimental demonstration of neuropeptide-receptor pairings combined with comprehensive analysis of genomic and/or transcriptomic sequence data indicate that, with the exception of the deuterostomian PrRP system, the… CONTINUE READING

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