The Evidence for Increased L1 Activity in the Site of Human Adult Brain Neurogenesis

@inproceedings{Kurnosov2015TheEF,
  title={The Evidence for Increased L1 Activity in the Site of Human Adult Brain Neurogenesis},
  author={Alexey A. Kurnosov and Svetlana V. Ustyugova and Vadim Nazarov and Anastasia A. Minervina and Alexander Yu. Komkov and Mikhail Shugay and Mikhail V Pogorelyy and Konstantin V. Khodosevich and Ilgar Z. Mamedov and Yuri B. Lebedev},
  booktitle={PloS one},
  year={2015}
}
Retroelement activity is a common source of polymorphisms in human genome. The mechanism whereby retroelements contribute to the intraindividual genetic heterogeneity by inserting into the DNA of somatic cells is gaining increasing attention. Brain tissues are suspected to accumulate genetic heterogeneity as a result of the retroelements somatic activity. This study aims to expand our understanding of the role retroelements play in generating somatic mosaicism of neural tissues. Whole-genome… CONTINUE READING