The Evidence Base of Proton Pump Inhibitor Chemopreventative Agents in Barrett's Esophagus—The Good, The Bad, and The Flawed!

Gastric acid is believed to be an important etiological factor in the pathogenesis of Barrett's esophagus. Pulsatile acid exposure increases cell proliferation in ex vivo Barrrett's tissue and normalization of esophageal pH reverses this. Proton pump inhibitors (PPIs) are the mainstay of therapy in Barrett's esophagus, and have numerous beneficial effects… CONTINUE READING