The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.

@article{Abe2011TheET,
  title={The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.},
  author={Haruka Abe and Makoto Okazawa and Shigetada Nakanishi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 30},
  pages={12497-502}
}
In the postnatal period, cerebellar granule cells express a set of the maturation gene battery in an activity-dependent manner and establish synaptic function in the cerebellar circuitry. Using primary cultures combined with specific inhibition of signaling cascades, the present investigation revealed that the expression of the maturation genes, including the NMDA glutamate receptor NR2C and GABA(A) receptor GABA(A)Rα6 genes, is controlled by strikingly unified signaling mechanisms that operate… CONTINUE READING