The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance

@article{AlonsoMagdalena2006TheEE,
  title={The Estrogenic Effect of Bisphenol A Disrupts Pancreatic $\beta$-Cell Function In Vivo and Induces Insulin Resistance},
  author={P. Alonso-Magdalena and S. Morimoto and C. Ripoll and E. Fuentes and A. Nadal},
  journal={Environmental Health Perspectives},
  year={2006},
  volume={114},
  pages={106 - 112}
}
The function of the pancreatic β-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17β-estradiol (E2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 μg/kg) of either E2 or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma… Expand
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