The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance

  title={The Estrogenic Effect of Bisphenol A Disrupts Pancreatic $\beta$-Cell Function In Vivo and Induces Insulin Resistance},
  author={Paloma Alonso-Magdalena and Sumiko Morimoto and Cristina Ripoll and Esther Fuentes and Angel Nadal},
  journal={Environmental Health Perspectives},
  pages={106 - 112}
The function of the pancreatic β-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17β-estradiol (E2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 μg/kg) of either E2 or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma… 

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Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β

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    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2005

Low Doses of Bisphenol A and Diethylstilbestrol Impair Ca2+ Signals in Pancreatic α-Cells through a Nonclassical Membrane Estrogen Receptor within Intact Islets of Langerhans

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Bisphenol A affects glucose transport in mouse 3T3‐F442A adipocytes

It was demonstrated that BPA, one of the chemicals that the authors intake incidentally, affects the glucose transport in adipocytes, and also that the environmental chemicals may be identified as one the environmental factors that affect diabetes and obesity.

Antidiabetic actions of estrogen: Insight from human and genetic mouse models

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A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas.

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Rapid insulinotropic effect of 17β‐estradiol via a plasma membrane receptor

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A Physiologically Based Approach To the Study of Bisphenol a and Other Estrogenic Chemicals On the Size of Reproductive Organs, Daily Sperm Production, and Behavior

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Low doses of the endocrine disruptor Bisphenol‐A and the native hormone 17β‐estradiol rapidly activate the transcription factor CREB

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