The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery.

@article{Wu2000TheEP,
  title={The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery.},
  author={Xiaoyun Wu and Cathy B Wilcox and Gina Devasahayam and Raymond L. Hackett and Miguel Ar{\'e}valo-Rodr{\'i}guez and Maria Elena Cardenas and Joseph Heitman and Steven D. Hanes},
  journal={The EMBO journal},
  year={2000},
  volume={19 14},
  pages={3727-38}
}
The Ess1/Pin1 peptidyl-prolyl isomerase (PPIase) is thought to control mitosis by binding to cell cycle regulatory proteins and altering their activity. Here we isolate temperature-sensitive ess1 mutants and identify six multicopy suppressors that rescue their mitotic-lethal phenotype. None are cell cycle regulators. Instead, five encode proteins involved in transcription that bind DNA, modify chromatin structure or are regulatory subunits of RNA polymerase II. A sixth suppressor, cyclophilin A… CONTINUE READING

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