The Escherichia coli heat-labile enterotoxin induces apoptosis of immature lymphocytes in vivo via a glucocorticoid-dependent pathway.

@article{Tamayo2005TheEC,
  title={The Escherichia coli heat-labile enterotoxin induces apoptosis of immature lymphocytes in vivo via a glucocorticoid-dependent pathway.},
  author={Esther Tamayo and Ram{\'o}n Merino and Jovanna Gonz{\'a}lez-Rojas and Regina Marquina and In{\'e}s Santiuste and Jos{\'e} Antonio Amado and Rino Rappuoli and Giuseppe Del Giudice and Jes{\'u}s Merino},
  journal={European journal of immunology},
  year={2005},
  volume={35 12},
  pages={3505-15}
}
Escherichia coli heat-labile enterotoxin (LT) exhibits a broad range of immunomodulatory activities, including the induction of lymphocyte-programmed cell death. However, the nature of the lymphoid populations sensitive to LT-induced apoptosis and the mechanisms used by this toxin to promote such activity are still unclear. In this study, we demonstrate that LT induces in mice a rapid increase in the levels of circulating corticosterone, resulting in a dramatic induction of cell death of… CONTINUE READING

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