The Escherichia coli TatABC system and a Bacillus subtilis TatAC-type system recognise three distinct targeting determinants in twin-arginine signal peptides.

@article{Mendel2008TheEC,
  title={The Escherichia coli TatABC system and a Bacillus subtilis TatAC-type system recognise three distinct targeting determinants in twin-arginine signal peptides.},
  author={Sharon Mendel and Andrew McCarthy and James Paul Barnett and Robyn T. Eijlander and Anja Nenninger and Oscar P. Kuipers and Colin Robinson},
  journal={Journal of molecular biology},
  year={2008},
  volume={375 3},
  pages={661-72}
}
The Tat system transports folded proteins across bacterial and thylakoid membranes. In Gram-negative organisms, it is encoded by tatABC genes and the system recognizes substrates bearing signal peptides with a conserved twin-arginine motif. Most Gram-positive organisms lack a tatB gene, indicating major differences in organisation and/or mechanism. Here, we have characterized the essential targeting determinants that are recognized by a Bacillus subtilis TatAC-type system, TatAdCd. Substitution… CONTINUE READING

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