The Escherichia coli Phospholipase PldA Regulates Outer Membrane Homeostasis via Lipid Signaling

Abstract

The outer membrane (OM) bilayer of Gram-negative bacteria is biologically unique in its asymmetrical organization of lipids, with an inner leaflet composed of glycerophospholipids (PLs) and a surface-exposed outer leaflet composed of lipopolysaccharide (LPS). This lipid organization is integral to the OM's barrier properties. Perturbations of the outer… (More)
DOI: 10.1128/mBio.00379-18

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