The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities.

  title={The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities.},
  author={Jeremy S. Edwards and Bernhard O. Palsson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 10},
  • J. Edwards, B. Palsson
  • Published 9 May 2000
  • Biology, Engineering
  • Proceedings of the National Academy of Sciences of the United States of America
The Escherichia coli MG1655 genome has been completely sequenced. The annotated sequence, biochemical information, and other information were used to reconstruct the E. coli metabolic map. The stoichiometric coefficients for each metabolic enzyme in the E. coli metabolic map were assembled to construct a genome-specific stoichiometric matrix. The E. coli stoichiometric matrix was used to define the system's characteristics and the capabilities of E. coli metabolism. The effects of gene… 

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