The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression.

@article{Tomoyasu1993TheEC,
  title={The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression.},
  author={Toshifumi Tomoyasu and Tsunetsugu Yuki and Shigeru Morimura and Hirotada Mori and Koji Yamanaka and Hironori Niki and Sota Hiraga and Teru Ogura},
  journal={Journal of bacteriology},
  year={1993},
  volume={175 5},
  pages={1344-51}
}
The ftsH gene is essential for cell viability in Escherichia coli. We cloned and sequenced the wild-type ftsH gene and the temperature-sensitive ftsH1(Ts) gene. It was suggested that FtsH protein was an integral membrane protein of 70.7 kDa (644 amino acid residues) with a putative ATP-binding domain. The ftsH1(Ts) gene was found to have two base substitutions within the coding sequence corresponding to the amino acid substitutions Glu-463 by Lys and Pro-587 by Ala. Homology search revealed… CONTINUE READING

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