The ErbB receptors and their role in cancer progression.

@article{Holbro2003TheER,
  title={The ErbB receptors and their role in cancer progression.},
  author={Thomas Holbro and Gianluca Civenni and Nancy E. Hynes},
  journal={Experimental cell research},
  year={2003},
  volume={284 1},
  pages={
          99-110
        }
}
The involvement of the ErbB receptor tyrosine kinases in human cancer, as well as their essential role in a variety of physiological events during normal development, have motivated the interest in this receptor family. Approaches taken to block the activity of ErbB receptors in cancer cells have not only proven that they drive in vitro tumor cell proliferation, but have also become clinically relevant for targeting tumors with deregulated ErbB signaling. The mechanisms and downstream effectors… CONTINUE READING
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