The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype.

@article{Vockerodt2008TheEV,
  title={The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype.},
  author={Martina Vockerodt and Stefanie L. Morgan and Michael Kuo and Wenbin Wei and Marilyn B Chukwuma and J. R. Arrand and Dieter Kube and Jonthan Gordon and Lawrence S Young and Ciaran B J Woodman and Paul Gerard Murray},
  journal={The Journal of pathology},
  year={2008},
  volume={216 1},
  pages={83-92}
}
Although the latent membrane protein-1 (LMP1) of the Epstein-Barr virus (EBV) is believed to be important for the transformation of germinal centre (GC) B cells, the precise contribution of this viral oncogene to lymphoma development is poorly understood. In this study, we used a non-viral vector-based method to express LMP1 in primary human GC B cells… CONTINUE READING