The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.


The Epstein-Barr virus (EBV) nuclear antigen (EBNA)-1 is the only viral protein expressed in all EBV-carrying malignancies, but its contribution to oncogenesis has remained enigmatic. We show that EBNA-1 induces chromosomal aberrations, DNA double-strand breaks, and engagement of the DNA damage response (DDR). These signs of genomic instability are… (More)
DOI: 10.1073/pnas.0810619106


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