The Epstein-Barr virus lytic transactivator Zta interacts with the helicase-primase replication proteins.

@article{Gao1998TheEV,
  title={The Epstein-Barr virus lytic transactivator Zta interacts with the helicase-primase replication proteins.},
  author={Zhancheng Gao and Anita Krithivas and Jon E. Finan and O. John Semmes and Sharleen X Zhou and Ya-Lin Wang and Stephen D. Hayward},
  journal={Journal of virology},
  year={1998},
  volume={72 11},
  pages={
          8559-67
        }
}
The Epstein-Barr virus transactivator Zta triggers lytic gene expression and is essential for replication of the lytic origin, oriLyt. Previous analysis indicated that the Zta activation domain contributed a replication-specific function. We now show that the Zta activation domain interacts with components of the EBV helicase-primase complex. The three helicase-primase proteins BBLF4 (helicase), BSLF1 (primase), and BBLF2/3 (primase-associated factor) were expressed fused to the Myc epitope… CONTINUE READING

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