The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase.

@article{Beisser2005TheEV,
  title={The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase.},
  author={Patrick S. Beisser and Dennis Verzijl and Yvonne K. Gruijthuijsen and Erik V.H. Beuken and Martine J. Smit and Rob Leurs and C. A. M. V. A. Bruggeman and Cornelis Vink},
  journal={Journal of virology},
  year={2005},
  volume={79 1},
  pages={441-9}
}
Epstein-Barr virus (EBV) infection is associated with many lymphoproliferative diseases, such as infectious mononucleosis and Burkitt's lymphoma. Consequently, EBV is one of the most extensively studied herpesviruses. Surprisingly, a putative G protein-coupled receptor (GPCR) gene of EBV, BILF1, has hitherto escaped attention, yet BILF1-like genes are conserved among all known lymphocryptovirus species, suggesting that they play a pivotal role in viral infection. To determine the function of… CONTINUE READING

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