The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.

@article{Strockbine1998TheEV,
  title={The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.},
  author={Laura D. Strockbine and Jeffrey I. Cohen and Terry Farrah and Stewart D. Lyman and F. O. O. Wagener and Robert F Dubose and Richard Armitage and Melanie K. Spriggs},
  journal={Journal of virology},
  year={1998},
  volume={72 5},
  pages={
          4015-21
        }
}
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus associated with infectious mononucleosis and several tumors. The BARF1 gene is transcribed early after EBV infection from the BamHI A fragment of the EBV genome. Evidence shown here indicates that the BARF1 protein is secreted into the medium of transfected cells and from EBV-carrying B cells induced to allow lytic replication of the virus. Expression cloning identified colony-stimulating factor-1 (CSF-1) as a ligand for BARF1. Computer… CONTINUE READING
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