The Epstein-Barr Virus-encoded miR-BART22 targets MAP3K5 to promote host cell proliferative and invasive abilities in nasopharyngeal carcinoma

@inproceedings{Chen2017TheEV,
  title={The Epstein-Barr Virus-encoded miR-BART22 targets MAP3K5 to promote host cell proliferative and invasive abilities in nasopharyngeal carcinoma},
  author={Ruichao Chen and Minfeng Zhang and Qiulian Li and Hanzhen Xiong and Shaoyan Liu and Weiyi Fang and Qianbing Zhang and Zhen Liu and Xuehu Xu and Qingping Jiang},
  booktitle={Journal of Cancer},
  year={2017}
}
miR-BART22, a new discovered Epstein-Barr virus (EBV) miRNA, is abundant in Nasopharyngeal carcinoma (NPC). It has been reported that miR-BART22 promoted the tumor development by down-modulating EBV LMP2 expression to evade the host immune response. But its cell target genes have still been obscure. We have reported an inverse correlation between the BART-22 and MAP3K5 protein expression in NPC tissues and NPC cell lines. Meanwhile, MAP3K5 protein expression level was significantly decreased in… CONTINUE READING
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