The Epstein–Barr virus and the pathogenesis of lymphoma

@article{Vockerodt2015TheEV,
  title={The Epstein–Barr virus and the pathogenesis of lymphoma},
  author={Martina Vockerodt and Lee Fah Yap and Claire Shannon-Lowe and Helen M Curley and Wenbin Wei and Katerina Vrzalikova and Paul G. Murray},
  journal={The Journal of Pathology},
  year={2015},
  volume={235}
}
Since the discovery in 1964 of the Epstein–Barr virus (EBV) in African Burkitt lymphoma, this virus has been associated with a remarkably diverse range of cancer types. Because EBV persists in the B cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of B‐cell lymphomas. However, EBV is also found in other cancers, including T‐cell/natural killer cell lymphomas and several epithelial malignancies. Explaining the aetiological role of EBV is… 
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The immune and viral mechanisms that establish whether EBV may coexist harmoniously with the immune system as in most of individuals or whether infection could result in one of the many EBV-associated malignancies are uncovered.
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EBV infection can modify important biological features of NPC cells, rendering them more vulnerable to both immunotherapy and targeted therapy, and may influence the use of targeted therapies for nasopharyngeal carcinoma.
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It is indicated that the current evidence for the presence and role of Epstein-Barr virus in CRC is insufficient and contradictory, and studies exploringEBV in colorectal adenoma-carcinoma sequence and its molecular genetic characteristics are largely missing and may significantly contribute to a better understanding of the role of EBV in CRC.
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The spectrum of EBV-associated diseases, the role of the encoded latent antigens, and the switch to latency or lytic replication which occurs in EBV infected cells are reviewed and the cellular processes and critical factors which contribute to cell transformation are described.
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TLDR
It is estimated that EBV-related cases from these six cancers accounted for 239,700–357,900 new cases and 137,900–208,700 deaths in 2020, highlighting the significant global impact of EBv-related cancers and extends the spectrum of disease that could benefit from anEBV-specific therapeutic.
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