The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell Invasion

@inproceedings{Fenouille2012TheET,
  title={The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell Invasion},
  author={Nina Fenouille and M{\'e}lanie Tichet and Maeva Dufies and Ana{\"i}s Pottier and Ariane Mogha and Julia K. Soo and St{\'e}phane Rocchi and Aude Mallavialle and Marie-Dominique Galibert and Amir Khammari and J T Lacour and Robert Ballotti and Marcel Deckert and Sophie Tartare-Deckert},
  booktitle={PloS one},
  year={2012}
}
During progression of melanoma, malignant melanocytes can be reprogrammed into mesenchymal-like cells through a process similar to epithelial-mesenchymal transition (EMT), which is associated with downregulation of the junctional protein E-cadherin and acquisition of a migratory phenotype. Recent evidence supports a role for SLUG, a transcriptional repressor of E-cadherin, as a melanocyte lineage transcription factor that predisposes to melanoma metastasis. However, the signals responsible for… CONTINUE READING