The Epithelial αvβ3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components

@inproceedings{Gianni2014TheE,
  title={The Epithelial αvβ3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components},
  author={Tatiana Gianni and Gabriella Campadelli-Fiume},
  booktitle={PLoS pathogens},
  year={2014}
}
TLR2 is a cell surface receptor which elicits an immediate response to a wide repertoire of bacteria and viruses. Its response is usually thought to be proinflammatory rather than an antiviral. In monocytic cells TLR2 cooperates with coreceptors, e.g. CD14, CD36 and αMβ2-integrin. In an earlier work we showed that αvβ3-integrin acts in concert with TLR2 to elicit an innate response to HSV, and to lipopolysaccharide. This response is characterized by production of IFN-α and -β, a specific set of… CONTINUE READING
6 Citations
53 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Similar Papers

Loading similar papers…