The Epigenomic Landscape in Osteoarthritis.

  title={The Epigenomic Landscape in Osteoarthritis.},
  author={Tommie C Simon and Matlock A. Jeffries},
  journal={Current rheumatology reports},
  volume={19 6},
PURPOSE OF REVIEW Epigenomics has emerged as a key player in our rapidly evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations, particularly DNA methylation, in OA pathogenesis; however, recent technological advances have resulted in numerous epigenome-wide studies examining in detail epigenetic modifications in OA. The purpose of this article is to introduce basic concepts in epigenetics and their recent applications to the study of osteoarthritis… CONTINUE READING
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  • M Stevenson, AC Annan, MB Humphrey
  • Curr Rheumatol Rep
  • 2017

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  • H Wang, H Zhang, Q Sun, Y Wang, J Yang
  • Mol Ther [ Internet ]
  • 2017

MicroRNA - 27 b regulates the expression of matrix

  • N Akhtar, Z Rasheed, S Ramamurthy, AN Anbazhagan, FR Voss, TM Haqqi
  • Curr Rheumatol Rep
  • 2017

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