The Epidemiology and Etiology of Keratoconus

@inproceedings{GordonShaag2012TheEA,
  title={The Epidemiology and Etiology of Keratoconus},
  author={Ariela Gordon-Shaag and Michel Millodot and Einat Shneor},
  year={2012}
}
Keratoconus is a noninflammatory disorder characterized by ectasia of the central or inferior portion of the cornea. This review presents the scant epidemiological information known to date and the factors believed to cause the development of the disease. They are the genetic factors for which evidence come from family studies, twin studies and genetic loci. There appears to be multiple genes causing a keratoconus phenotype with variable penetration. However, the genetic predisposition might… 

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References

SHOWING 1-10 OF 108 REFERENCES
Blue sclerae and keratoconus: Key features of a distinct heritable disorder of connective tissue
A syndrome of keratoconus, blue sclerae, middle ear bony conduction defect and spondylolisthesis occurring in a brother and sister born to consanguineous parents is described. Eleven similar cases
Keratoconus and atopic diseases.
TLDR
Investigation of individual conditions, such as asthma, hay fever, connective tissue syndromes, and eye rubbing, and the relationship of keratoconus found it to be found that the prevalence of asthma rises from 0.4% to 1% in the control group to 17.9%" in the keratconus group, or an eighteenfold increase.
Keratoconus: a review.
On the Location of the Cone and the Etiology of Keratoconus
I suggest that the location of the cone in keratoconus is most often located in the paracentral inferonasal quadrant of the cornea due to the presence of the most senile epithelial cells in this
Keratoconus and coexisting atopic disease.
TLDR
It is found that atopic traits are more common in patients with keratoconus than in general ophthalmic patients and markedly so in those cases with associated atopic disease.
Leber congenital amaurosis and its association with keratoconus and keratoglobus.
  • M. Elder
  • Medicine
    Journal of pediatric ophthalmology and strabismus
  • 1994
TLDR
Keratoconus seems specifically associated with Leber amaurosis, probably due to genetic factors, rather than poor visual acuity per se.
Keratoconus caused by eye rubbing in patients with Tourette Syndrome.
TLDR
A possible association between TS and keratoconus exists with chronic eye rubbing being the suggested mechanism and eye rubbing seems to be an important causative factor for keratconus.
Genetic epidemiological study of keratoconus: evidence for major gene determination.
TLDR
Strong evidence of familial aggregation is observed in KC and its subclinical indices and this aggregation is likely due to a major gene effect.
...
1
2
3
4
5
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