The Ephrin VAB-2/EFN-1 Functions in Neuronal Signaling to Regulate Epidermal Morphogenesis in C. elegans

@article{ChinSang1999TheEV,
  title={The Ephrin VAB-2/EFN-1 Functions in Neuronal Signaling to Regulate Epidermal Morphogenesis in C. elegans},
  author={Ian Chin-Sang and Sean George and Mei Ding and Sarah L Moseley and Andrew S. Lynch and Andrew D. Chisholm},
  journal={Cell},
  year={1999},
  volume={99},
  pages={781-790}
}
The Eph receptor VAB-1 is required in neurons for epidermal morphogenesis during C. elegans embryogenesis. Two models were proposed for the non-autonomous role of VAB-1: neuronal VAB-1 might signal directly to epidermis, or VAB-1 signaling between neurons might be required for epidermal development. We show that the ephrin VAB-2 (also known as EFN-1) is a ligand for VAB-1 and can function in neurons to regulate epidermal morphogenesis. In the absence of VAB-1 signaling, ephrin-expressing… CONTINUE READING

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Identification and cloning tern to trunk neural crest migration

  • H. J. Cheng, J. G. Flanagan
  • Curr. Biol
  • 1994
Highly Influential
12 Excerpts

nate specific ligand oligomers

  • J. G. Flanagan, P. Vanderhaeghen
  • Annu. Rev. Neurosci
  • 1998
Highly Influential
3 Excerpts

Eph receptors

  • G. Mellitzer, Q. Xu, D. G. Wilkinson
  • 1999
2 Excerpts

Characterization of the genes Development

  • D. P. Cerretti, N. Nelson
  • 1998

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