The EphA4 receptor tyrosine kinase is necessary for the guidance of nasal retinal ganglion cell axons in vitro.


The retinotectal projection serves as a model system for the study of topographic projections. It has been shown in the past few years that members of the Eph family are strongly involved in establishing this projection. The analysis so far has focused on a characterization of Ephrin ligands which are expressed in a gradient in both the tectum and the… (More)