The Epac-Rap1 signaling pathway controls cAMP-mediated exocytosis of Weibel-Palade bodies in endothelial cells.

@article{Hooren2012TheES,
  title={The Epac-Rap1 signaling pathway controls cAMP-mediated exocytosis of Weibel-Palade bodies in endothelial cells.},
  author={Kathinka W. E. M. van Hooren and Ellen L. van Agtmaal and Mar Fernandez-Borja and Jan Bernardus Antonius van Mourik and Jan Voorberg and Ruben Bierings},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 29},
  pages={24713-20}
}
Endothelial cells contain specialized storage organelles called Weibel-Palade bodies (WPBs) that release their content into the vascular lumen in response to specific agonists that raise intracellular Ca(2+) or cAMP. We have previously shown that cAMP-mediated WPB release is dependent on protein kinase A (PKA) and involves activation of the small GTPase RalA. Here, we have investigated a possible role for another PKA-independent cAMP-mediated signaling pathway in the regulation of WPB… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

2011)MyosinVa acts in concert with Rab27a andMyRIP to regulate acute vonWillebrand factor release from endothelial cells.Traffic

I. Rojo Pulido, T. D. Nightingale, +3 authors V. andGerke
2011
View 1 Excerpt

MyosinVa acts in concert with Rab 27 a andMyRIP to regulate acute vonWillebrand factor release from endothelial cells

I. Rojo Pulido, T. D. Nightingale, +3 authors V. andGerke
Traffic • 2011

Similar Papers

Loading similar papers…