The Environment, Epigenetics and Amyloidogenesis

@article{Wu2007TheEE,
  title={The Environment, Epigenetics and Amyloidogenesis},
  author={Jinfang Wu and Md. Riyaz Basha and Nasser Zawia},
  journal={Journal of Molecular Neuroscience},
  year={2007},
  volume={34},
  pages={1-7}
}
Alzheimer’s Disease (AD) is a progressive, irreversible neurodegenerative disease. Despite several genetic mutations (Haass et al., J. Biol. Chem. 269:17741–17748, 1994; Ancolio et al., Proc. Natl. Acad. Sci. USA 96:4119–4124, 1999; Munoz and Feldman, CMAJ 162:65–72, 2000; Gatz et al., Neurobiol. Aging 26:439–447, 2005) found in AD patients, more than 90% of AD cases are sporadic (Bertram and Tanzi, Hum. Mol. Genet. 13:R135–R141, 2004). Therefore, it is plausible that environmental exposure may… CONTINUE READING

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