The Enigmas of Kaposi's Sarcoma

@article{Gallo1998TheEO,
  title={The Enigmas of Kaposi's Sarcoma},
  author={Robert C Gallo},
  journal={Science},
  year={1998},
  volume={282},
  pages={1837 - 1839}
}
  • R. Gallo
  • Published 4 December 1998
  • Medicine
  • Science
Kaposi9s sarcoma, a disfiguring skin leasion, is a common occurence in patients with AIDS. In this summary, Robert Gallo outlines current thinking about the biological underpinnings of this tumor. He discusses how it develops and whether it is truly neoplastic. 
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203 Citations
Highly Influential Citations
9
Background Citations
66
Methods Citations
1

203 Citations

Non-HIV-related Kaposi's sarcoma in former colonists/expatriates in Central Africa.
TLDR
Two cases of Kaposi's sarcoma that occurred in patients who had no evident risk factors for KS but who were former colonists/expatriates in Central Africa are reported and may represent a hitherto unrecognized epidemiological form of KS.
The world‐wide incidence of Kaposi's sarcoma in the HIV/AIDS era
TLDR
Kaposi's sarcoma is a multicentric angioproliferative cancer of endothelial origin typically occurring in the context of immunosuppression or immunodeficiency and frequently occurs among transplant recipients.
Kaposi's sarcoma in the era of HAART-an update on mechanisms, diagnostics and treatment.
Kaposi's Sarcoma (KS) signified the AIDS epidemic in the 1980's and led to the discovery of the eighth human herpesvirus, KS-associated herpesvirus (KSHV), as the causative agent for this disease.…
An Update on Kaposi’s Sarcoma: Epidemiology, Pathogenesis and Treatment
TLDR
It is now important for clinicians to be mindful of Kaposi’s sarcoma manifesting in a growing variety of clinical contexts.
Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma.
Pathogenesis of Kaposi's sarcoma.
Kaposi’s Sarcoma and Other HHV-8 Associated Tumors
TLDR
As medical students in 1987 at Kalafong Hospital, South Africa, this was the first patient they had seen who was infected with the human immunodeficiency virus (HIV), and he had Kaposi’s sarcoma, and they never imagined then that 10 years later most patients at this hospital would have AIDS-related illnesses.
Classic Kaposi's sarcoma: a case report.
TLDR
A 60-year-old male from the Mediterranean area presented with edematous right leg and livid nodules and macules on the skin of upper and lower extremities, confirming the diagnosis of the classic form of Kaposi's sarcoma.
Association between Kaposi's sarcoma and squamous cell carcinoma of the larynx
  • S. Motta, G. Motta
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2005
Enhancement of Classic Kaposi’s Sarcoma Growth after Intralesional Injections of Desferrioxamine
TLDR
An 85-year-old man with classic KS is treated with 5 weekly intralesional injections of DFO and the DFO-treated lesion was characterised by the development of numerous KS papules within the drug diffusion area, whereas no change was noted in untreated or control saline-treated lesions, suggesting that intralESional iron chelators are not indicated in patients with KS.
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References

SHOWING 1-10 OF 29 REFERENCES
Evidence for multiclonality in multicentric Kaposi's sarcoma.
  • P. Gill, Y. Tsai, P. Jones
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
It is suggested that KS can be a clonal neoplasm, and in some of the cases multiple KS lesions in a given patient can arise from independent cellular origins and acquire clonal characteristics.
Monoclonal origin of multicentric Kaposi's sarcoma lesions.
TLDR
Data indicate that Kaposi's sarcoma is a disseminated monoclonal cancer and that the changes that permit the clonal outgrowth of spindle cells occur before the disease spreads.
Some aspects of the pathogenesis of HIV-1-associated Kaposi's sarcoma.
  • R. Gallo
  • Biology, Medicine
    Journal of the National Cancer Institute. Monographs
  • 1998
TLDR
It is concluded that there is little evidence that HHV-8 is a transforming virus as has been repeatedly suggested and that its role in KS is more likely to be indirect (like HIV-1), perhaps necessary but hardly likely to been sufficient for KS development.
Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines.
TLDR
It is shown that malignant KS cell lines do not harbor herpesvirus-like DNA sequences while B cells, CD14+ and CD34+ cells do, suggesting that if a KS malignancy originates from infection with HHV-8, the virus can be lost and is not necessary for maintenance of the neoplastic state.
Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone
TLDR
Evidence is provided that KS can evolve into a malignancy and have implications for the hormonal treatment of this tumour.
AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects.
TLDR
It is shown that the AIDS-KS cells express messenger RNA for a complex mixture of cytokines that correlate with several of the biological activities of these cells, which seem to account for a large proportion of the activities.
KSHV and Kaposi's Sarcoma: The End of the Beginning?
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
TLDR
unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus
TLDR
Investigating the biological consequences of infecting human primary endothelial cells with purified KSHV particles finds that infection causes long-term proliferation and survival of these cells, which are associated with the acquisition of telomerase activity and anchorage-independent growth.
Deletion and translocation involving chromosome 3 (p14) in two tumorigenic Kaposi's sarcoma cell lines.
TLDR
This is the first time nonrandom chromosomal alterations have been described in KS neoplastic cells and it is demonstrated that both cell lines are aneuploid and have some additional features in common, i.e., loss of copies of chromosomes 14 and 21 and nonrandom translocations and deletions in the short arm of chromosome 3 at region 3p14.
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