The Enigma of Store-Operated Ca2+-Entry in Neurons: Answers from the Drosophila Flight Circuit

@inproceedings{Hasan2010TheEO,
  title={The Enigma of Store-Operated Ca2+-Entry in Neurons: Answers from the Drosophila Flight Circuit},
  author={Gaiti Hasan and Gayatri Venkiteswaran},
  booktitle={Front. Neural Circuits},
  year={2010}
}
In neurons a well-defined source of signaling Ca(2+) is the extracellular medium. However, as in all metazoan cells, Ca(2+) is also stored in endoplasmic reticular compartments inside neurons. The relevance of these stores in neuronal function has been debatable. The Orai gene encodes a channel that helps refill these stores from the extracellular medium in non-excitable cells through a process called store-operated Ca(2+) entry or SOCE. Recent findings have shown that raising the level of Orai… CONTINUE READING