The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain.

Abstract

Interaction of Zn(2+) with the metal-binding domain of the English (H6R) amyloid-β mutant results in the formation of peptide dimers. The mutation causes the exclusion of His6 from the zinc chelation pattern observed in the intact domain and triggers the assembly of the dimers via zinc ions coordinated by (11)EVHH(14) fragments.

DOI: 10.1039/c4mt00259h
0200400600201520162017
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@article{Kozin2015TheE, title={The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain.}, author={Sergey A Kozin and Alexandra A Kulikova and Andrey N Istrate and Philipp O. Tsvetkov and Sergey S Zhokhov and Yu V Mezentsev and Olga I Kechko and Alexis S. Ivanov and Vladimir I Polshakov and Alexander A. Makarov}, journal={Metallomics : integrated biometal science}, year={2015}, volume={7 3}, pages={422-5} }