The Endothelin System in Human Glioblastoma

  title={The Endothelin System in Human Glioblastoma},
  author={Giorgia Egidy and Lucie Peduto Eberl and Olivier Valdenaire and Martin Irmler and Rachid Majdi and A. -C. Diserens and Adriano Fontana and R. Janzer and Florence Pinet and Lucienne Juillerat-Jeanneret},
  journal={Laboratory Investigation},
Endothelin-1 (ET-1) is a powerful mitogenic and/or anti-apoptotic peptide produced by many cancer cells. To evaluate the potential role of the endothelin system in glioblastoma we first determined the cellular distribution of the mRNA and proteins of the components of the endothelin system, preproendothelin-1 (PPET-1), endothelin-converting enzyme-1 (ECE-1), and ETA and ETB receptors in human glioblastoma tissue and glioblastoma cell lines. PPET-1, ECE-1, and ETA receptor were highly expressed… CONTINUE READING