The Endocrine Regulation of Aging by Insulin-like Signals

@article{Tatar2003TheER,
  title={The Endocrine Regulation of Aging by Insulin-like Signals},
  author={Marc Tatar and Andrzej Bartke and Adam Antebi},
  journal={Science},
  year={2003},
  volume={299},
  pages={1346 - 1351}
}
Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and rodents. In the nematode and the fly, secondary hormones downstream of insulin-like signaling appear to regulate aging. In mammals, the order in which the hormones act is unresolved because insulin, insulin-like growth factor–1, growth hormone, and thyroid hormones are interdependent. In all species examined to date, endocrine manipulations can slow aging without concurrent costs in reproduction, but… Expand
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