The Endocannabinoid System as a Target for the Treatment of Visceral Obesity and Metabolic Syndrome

  title={The Endocannabinoid System as a Target for the Treatment of Visceral Obesity and Metabolic Syndrome},
  author={Ioannis Kyrou and George Valsamakis and Constantine Tsigos},
  journal={Annals of the New York Academy of Sciences},
Abstract:  The endogenous cannabinoid system is a novel, remarkably elaborate physiological signaling system, comprising the recently identified endogenous cannabinoid ligands, their corresponding selective receptors, and the machinery of proteins and enzymes that is involved in their biosynthesis, release, transport, and degradation. This system extends widely in both the central nervous system (CNS) and the periphery and exhibits a variety of actions implicated in vital functions (e.g… 

The Endocannabinoid System as a Novel Approach for Managing Obesity

  • J. Lillo
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    The Journal of the American Osteopathic Association
  • 2007
Rimonabant is the first cannabinoid receptor 1 antagonist to be marketed in Europe and the first to file an New Drug Application in the United States and may provide a novel therapeutic strategy for the treatment of patients with obesity and associated cardiometabolic risk factors.

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These adrenocortical perturbations contribute to the development of metabolic syndrome at both the paracrine and systemic level by favoring the physiological dysregulation of organs responsive to aldosterone, GC, and/or androgens, including adipose tissue.

Cannabinoid-1 receptor blockade in cardiometabolic risk reduction: efficacy.

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Genetic studies on this system in eating disorders and obesity and studies locating cannabinoid receptors in areas related to food intake suggest cannabinoid hyperactivity in obesity, and this excessive activity may have prognostic implications.

18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity.

Results may provide a novel insight into the molecular mechanism involved in anti-adipogenic and anti-obesity effects of 18β-GA by suppressing the activation of CB1R induced by AEA and may exert beneficial effects against obesity-related metabolic disorders.

Rimonabant, a Selective Cannabinoid CB1 Receptor Antagonist, Inhibits Atherosclerosis in LDL Receptor–Deficient Mice

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The Effect of Gender and Rimonabant on Energy Expenditure, Gene Expression and Body Fat Distribution in Obesity.

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The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions.

Food for thought: endocannabinoid modulation of lipogenesis.

A report in this issue of the JCI demonstrates the presence of a common endocannabinoid-regulated molecular pathway for peripheral lipogenic and central appetitive regulation in the liver and hypothalamus.

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  • E. Fride
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  • 2002
The role of the endocannabinoid system in appetite stimulation in the adult organism, and perhaps more importantly, its critical involvement in milk ingestion and survival of the newborn, may not only further the understanding of the physiology of food intake and growth, but may also find therapeutic applications in wasting disease and infant's "failure to thrive".

The endocannabinoid system: a general view and latest additions

The latest ‘additions’ to the endocannabinoid system are reviewed together with earlier breakthroughs that have contributed to the present knowledge of the biochemistry and pharmacology of theendocannabinoids.

Endocannabinoids in the regulation of appetite and body weight

  • T. Kirkham
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    Behavioural pharmacology
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Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice.

This chapter reviews the main results obtained with these lines of CB1 knockout mice in several physiological responses that have been previously related to the activity of the endocannabinoid system and provides an update of the apparently controversial data reported in the literature.

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The findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity and increased in mature human adipocytes compared with in preadipocytes and was found in several human tissues.

Central and Peripheral Signaling Mechanisms Involved in Endocannabinoid Regulation of Feeding: A Perspective on the Munchies

The endocannabinoid system is a critical regulator of energy homeostasis and food intake both by modulating the inputs to various brain areas that monitor energy balance and by increasing the hedonic or reward value of the food consumed.

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