The Endocannabinoid System and Energy Metabolism

@article{Bellocchio2008TheES,
  title={The Endocannabinoid System and Energy Metabolism},
  author={Luigi Bellocchio and Cristina Cervino and Renato Pasquali and Uberto Pagotto},
  journal={Journal of Neuroendocrinology},
  year={2008},
  volume={20}
}
Many different regulatory actions have been attributed to endocannabinoids, and their involvement in several pathophysiological conditions is under intense scrutiny. Cannabinoid receptors [cannabinoid receptor type 1 (CB1) and CB2] participate in the physiological modulation of many central and peripheral functions. The ability of the endocannabinoid system to control appetite, food intake and energy balance has recently received considerable attention, particularly in the light of the… 
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References

SHOWING 1-10 OF 78 REFERENCES
Endocannabinoids and the control of energy balance
The emerging role of the endocannabinoid system in endocrine regulation and energy balance.
TLDR
The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions.
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
TLDR
A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.
Cannabinoid receptor signaling directly inhibits thermogenesis and alters expression of adiponectin and visfatin.
TLDR
Here, the first evidence for direct Cb1 receptor-mediated actions in brown and white adipocytes is presented, which negatively impacts thermogenesis in brown adipocytes while favoring a positive energy balance by differentially regulating the novel adipokine visfatin as well as adiponectin in white adipocyte.
Endogenous cannabinoid system as a modulator of food intake
TLDR
The aim of this review is to provide an extensive overview on the role of this neuromodulatory system in feeding behavior by summarizing the most relevant data obtained from human and animal studies and by elucidating the interactions of the cannabinoid system with the most important neuronal networks and metabolic pathways involved in the control of food intake.
Activation of the peripheral endocannabinoid system in human obesity.
TLDR
The findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity and increased in mature human adipocytes compared with in preadipocytes and was found in several human tissues.
Leptin-regulated endocannabinoids are involved in maintaining food intake
TLDR
It is shown that following temporary food restriction, CB1 receptor knockout mice eat less than their wild-type littermates, and the CB1 antagonist SR141716A reduces food intake in wild- type but not knockout mice, which indicates that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin.
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.
TLDR
It is concluded that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation.
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