The Endocannabinoid System and Energy Metabolism

@article{Bellocchio2008TheES,
  title={The Endocannabinoid System and Energy Metabolism},
  author={Luigi Bellocchio and Cristina Cervino and Renato Pasquali and Uberto Pagotto},
  journal={Journal of Neuroendocrinology},
  year={2008},
  volume={20}
}
Many different regulatory actions have been attributed to endocannabinoids, and their involvement in several pathophysiological conditions is under intense scrutiny. Cannabinoid receptors [cannabinoid receptor type 1 (CB1) and CB2] participate in the physiological modulation of many central and peripheral functions. The ability of the endocannabinoid system to control appetite, food intake and energy balance has recently received considerable attention, particularly in the light of the… 
View on Wiley
onlinelibrary.wiley.com
112 Citations
Highly Influential Citations
5
Background Citations
49

112 Citations

Citation Type

Citation Type

[A role for the endocannabinoid system in obesity].
TLDR
The role of the endocannabinoid system in metabolic pathways associated to control mechanisms of energy balance and its involvement in overweight and obesity is discussed.
The endocannabinoid system and its relevance for nutrition.
TLDR
The main features of the ECS are summarized in order to put in better focus current knowledge of the nutritional relevance of endocannabinoid signaling and of its role in obesity, cardiovascular pathologies, and gastrointestinal diseases.
The endocannabinoid system and migraine
Re-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases
TLDR
Targeting the endocannabinoid system using novel peripheral CB1 receptor blockers with negligible penetrance across the blood-brain barrier may prove to be effective therapy for obesity and its co-morbidities.
Peripheral effects of the endocannabinoid system in energy homeostasis: Adipose tissue, liver and skeletal muscle
TLDR
This review aims to summarize the recent advances that have been made regarding the role the ECS plays in crucial peripheral systems pertaining to energy homeostasis: adipose tissues, the liver and skeletal muscle.
Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation
TLDR
A brief history of cannabinoids and the protagonists of the endocannabinoidergic system, i.e. synthesis and degradation enzymes and main receptors, and the pharmacological effects of cannabinoids will be outlined.
Cannabinoids and the gut: new developments and emerging concepts.
Classical endocannabinoid‐like compounds and their regulation by nutrients
TLDR
The endogenous formation of these N‐acylethanolamines in the small intestine may serve an important role in regulating food intake, through signaling via PPARα and the vagus nerve to the brain appetite center, and the hyperphagic effect of high‐fat diet.
Neuroanatomical basis for therapeutic applications of cannabinoid receptor 1 antagonists
TLDR
The ongoing elucidation and characterization of the neuroanatomical circuitry within which the CB1 cannabinoid receptor and endocannabinoids are localized to modulate these psychological and physiological processes continues to suggest therapeutic applications for cannabinoid antagonists and inverse agonists.
The endocannabinoid system and appetite: relevance for food reward
TLDR
A better understanding of the role of the ECS in the rewarding value of specific foods or diets could offer new possibilities to optimise the balance between energy and nutrient intake for different target groups.
...
...

References

SHOWING 1-10 OF 78 REFERENCES
Endocannabinoids and the control of energy balance
The emerging role of the endocannabinoid system in endocrine regulation and energy balance.
TLDR
The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions.
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
TLDR
A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.
Cannabinoid receptor signaling directly inhibits thermogenesis and alters expression of adiponectin and visfatin.
TLDR
Here, the first evidence for direct Cb1 receptor-mediated actions in brown and white adipocytes is presented, which negatively impacts thermogenesis in brown adipocytes while favoring a positive energy balance by differentially regulating the novel adipokine visfatin as well as adiponectin in white adipocyte.
Endogenous cannabinoid system as a modulator of food intake
TLDR
The aim of this review is to provide an extensive overview on the role of this neuromodulatory system in feeding behavior by summarizing the most relevant data obtained from human and animal studies and by elucidating the interactions of the cannabinoid system with the most important neuronal networks and metabolic pathways involved in the control of food intake.
Effects of cannabinoid receptors on skeletal muscle oxidative pathways
Cannabinoid receptors regulate Ca2+ signals and insulin secretion in pancreatic β-cell
Activation of the peripheral endocannabinoid system in human obesity.
TLDR
The findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity and increased in mature human adipocytes compared with in preadipocytes and was found in several human tissues.
Leptin-regulated endocannabinoids are involved in maintaining food intake
TLDR
It is shown that following temporary food restriction, CB1 receptor knockout mice eat less than their wild-type littermates, and the CB1 antagonist SR141716A reduces food intake in wild- type but not knockout mice, which indicates that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin.
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.
TLDR
It is concluded that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation.
...
...