The Endocannabinoid System Protects Rat Glioma Cells Against HIV-1 Tat Protein-induced Cytotoxicity

  title={The Endocannabinoid System Protects Rat Glioma Cells Against HIV-1 Tat Protein-induced Cytotoxicity},
  author={Giuseppe Esposito and Alessia Ligresti and Angelo A. Izzo and Tiziana Bisogno and Menotti Ruvo and Massimo Di Rosa and Vincenzo Di Marzo and Teresa Iuvone},
  journal={The Journal of Biological Chemistry},
  pages={50348 - 50354}
Cannabinoids modulate nitric oxide (NO) levels in cells of the central nervous system. Here we studied the effect of cannabinoid CB1 and CB2receptor agonists on the release of NO and cell toxicity induced by the human immuno-deficiency virus-1 Tat protein (HIV-1 Tat) in rat glioma C6 cells. The CB1 and CB2 agonist WIN 55,212–2 inhibited the expression of inducible NO synthase (iNOS) and NO release caused by treatment of C6 cells with HIV-1 Tat and interferon-γ (IFN-γ). The effect of WIN 55,212… 

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