The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

@article{Monory2006TheES,
  title={The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus},
  author={Krisztina Monory and Federico Massa and Michaela Egertov{\'a} and Matthias Eder and Heike Blaudzun and Ruth E. Westenbroek and Wolfgang Kelsch and Wolfgang Jacob and Rudolf Marsch and Morten Ekker and J. Long and John L. R. Rubenstein and Sandra Goebbels and K Nave and Matthew John During and Matthias Klugmann and Barbara W{\"o}lfel and Hans-Ulrich Dodt and Walter Prof. Dr.med. Zieglg{\"a}nsberger and Carsten T. Wotjak and Ken Mackie and Maurice R Elphick and Giovanni Marsicano and B. E. P. Lutz},
  journal={Neuron},
  year={2006},
  volume={51},
  pages={455-466}
}
Balanced control of neuronal activity is central in maintaining function and viability of neuronal circuits. The endocannabinoid system tightly controls neuronal excitability. Here, we show that endocannabinoids directly target hippocampal glutamatergic neurons to provide protection against acute epileptiform seizures in mice. Functional CB1 cannabinoid receptors are present on glutamatergic terminals of the hippocampal formation, colocalizing with vesicular glutamate transporter 1 (VGluT1… CONTINUE READING
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