The Endocannabinoid System: Novel Pathway for Cardiometabolic Risk‐Factor Reduction

@article{Woods2007TheES,
  title={The Endocannabinoid System: Novel Pathway for Cardiometabolic Risk‐Factor Reduction},
  author={Stephen C. Woods},
  journal={Journal of the American Academy of Physician Assistants},
  year={2007},
  volume={20},
  pages={7–10}
}
  • S. Woods
  • Published 1 November 2007
  • Biology, Medicine
  • Journal of the American Academy of Physician Assistants
Although rimonabant has been approved for use in several countries, the Food and Drug Administration has expressed concern about the potential for adverse neurologic and psychiatric effects, considering the widespread distribution of CB1 receptors in the brain. While more research is clearly needed, the clinical evidence shows that CB1-receptor blockade with rimonabant improves multiple cardiovascular and metabolic variables, including body weight and waist circumference, HDL-C, triglycerides… 
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TLDR
Selective CB1-receptor blockade with rimonabant significantly reduces body weight and waist circumference and improves the profile of several metabolic risk factors in high-risk patients who are overweight or obese and have an atherogenic dyslipidemia.
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It is concluded that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation.
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