The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs)

  title={The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs)},
  author={Gerwyn Morris and Michael Berk and Piotr Gałecki and Michael Maes},
  journal={Molecular Neurobiology},
The World Health Organization classifies myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs) as a nervous system disease. Together with other diseases under the G93 heading, ME/cfs shares a triad of abnormalities involving elevated oxidative and nitrosative stress (O&NS), activation of immuno-inflammatory pathways, and mitochondrial dysfunctions with depleted levels of adenosine triphosphate (ATP) synthesis. There is also abundant evidence that many patients with ME/cfs (up to around 60… 

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Recent findings were compiled and placed in the context of the clinical picture and natural history of the disease, giving rise to an explanatory model, and the hypothesis generates testable propositions that can augment the understanding of the pathogenesis of ME/CFS.

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections

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A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome

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Prospective Biomarkers from Plasma Metabolomics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Implicate Redox Imbalance in Disease Symptomatology

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Investigating the profile of markers of immune function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients found immunological abnormalities which may serve as biomarkers in CFS/ME patients with potential for an application as a diagnostic tool.

IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression

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The results show that lowered levels of CoQ10 play a role in the pathophysiology of Myalgic encephalomyelitis/chronic fatigue syndrome and that symptoms, such as fatigue, and autonomic and neurocognitive symptoms may be caused by Coq10 depletion, and that patients with ME/CFS should be regarded as a relative contraindication for treatment with statins without Co Q10 supplementation.

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

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Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue?

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Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis

Investigation of Natural Killer cell cytotoxic activity, NK cell subsets and cytokines in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis confirmed decreases in immune function in patients, suggesting an increased susceptibility to viral and other infections.