The Emerging Paradigm of Network Medicine in the Study of Human Disease

@article{Chan2012TheEP,
  title={The Emerging Paradigm of Network Medicine in the Study of Human Disease},
  author={Stephen Y. Chan and Joseph Loscalzo},
  journal={Circulation Research},
  year={2012},
  volume={111},
  pages={359–374}
}
The molecular pathways that govern human disease consist of molecular circuits that coalesce into complex, overlapping networks. These network pathways are presumably regulated in a coordinated fashion, but such regulation has been difficult to decipher using only reductionistic principles. The emerging paradigm of “network medicine” proposes to utilize insights garnered from network topology (eg, the static position of molecules in relation to their neighbors) as well as network dynamics (eg… 

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