The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein.

@article{Fellows2000TheES,
  title={The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein.},
  author={Jane Fellows and Hediye Erdjument-Bromage and Paul Tempst and Jesper Qualmann Svejstrup},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 17},
  pages={12896-9}
}
A novel yeast gene, ELP2, is shown to encode the 90-kDa subunit of the Elongator complex and elongating RNA polymerase II holoenzyme. ELP2 encodes a protein with eight WD40 repeats, and cells lacking the gene display typical elp phenotypes, such as temperature and salt sensitivity. Generally, different combinations of double and triple ELP gene deletions cause the same phenotypes as single ELP1, ELP2, or ELP3 deletion, providing genetic evidence that the ELP gene products work together in a… CONTINUE READING
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