The Elongator Complex Interacts with PCNA and Modulates Transcriptional Silencing and Sensitivity to DNA Damage Agents

@inproceedings{Li2009TheEC,
  title={The Elongator Complex Interacts with PCNA and Modulates Transcriptional Silencing and Sensitivity to DNA Damage Agents},
  author={Qing Li and Afsaneh Fazly and Hui Zhou and Shengbing Huang and Zhiguo Zhang and Bruce W. Stillman},
  booktitle={PLoS genetics},
  year={2009}
}
Histone chaperones CAF-1 and Asf1 function to deposit newly synthesized histones onto replicating DNA to promote nucleosome formation in a proliferating cell nuclear antigen (PCNA) dependent process. The DNA replication- or DNA repair-coupled nucleosome assembly pathways are important for maintenance of transcriptional gene silencing and genome stability. However, how these pathways are regulated is not well understood. Here we report an interaction between the Elongator histone… CONTINUE READING

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