The Elg1 Clamp Loader Plays a Role in Sister Chromatid Cohesion

@article{Parnas2009TheEC,
  title={The Elg1 Clamp Loader Plays a Role in Sister Chromatid Cohesion},
  author={Oren Parnas and Adi Zipin-Roitman and Yuval Mazor and Batia Liefshitz and Shay Ben-Aroya and Martin Kupiec},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={552 - 557}
}
Mutations in the ELG1 gene of yeast lead to genomic instability, manifested in high levels of genetic recombination, chromosome loss, and gross chromosomal rearrangements. Elg1 shows similarity to the large subunit of the Replication Factor C clamp loader, and forms a RFC-like (RLC) complex in conjunction with the 4 small RFC subunits. Two additional RLCs exist in yeast: in one of them the large subunit is Ctf18, and in the other, Rad24. Ctf18 has been characterized as the RLC that functions in… CONTINUE READING