The Electrophysiological Properties of Diphenylhydantoin Sodium as Compared to Procaine Amide in the Normal and Digitalis‐Intoxicated Heart

@article{Helfant1967TheEP,
  title={The Electrophysiological Properties of Diphenylhydantoin Sodium as Compared to Procaine Amide in the Normal and Digitalis‐Intoxicated Heart},
  author={R. Helfant and B. Scherlag and A. Damato},
  journal={Circulation},
  year={1967},
  volume={36},
  pages={108–118}
}
The effects of diphenylhydantoin sodium (Dilantin) on ventricular automaticity, intraventricular conduction, atrioventricular (A-V) conduction, and sinus rate have been determined in the digitalis-intoxicated and normal heart. These effects have been compared with procaine amide. Diphenylhydantoin sodium depresses ventricular automaticity and enhances A-V conduction while having little or no effect on intraventricular conduction or sinus rate. Procaine amide differed from diphenylhydantoin… Expand
Effects of Diphenylhydantoin on Excitability and Automaticity in the Canine Heart
Diphenylhydantoin: pharmacological and clinical use.
  • A. Damato
  • Medicine
  • Progress in cardiovascular diseases
  • 1969
The effects of diphenylhydantoin on mechanical and electrical properties of isolated cat myocardium
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