The Electrophysiological Properties of Diphenylhydantoin Sodium as Compared to Procaine Amide in the Normal and Digitalis‐Intoxicated Heart

@article{Helfant1967TheEP,
  title={The Electrophysiological Properties of Diphenylhydantoin Sodium as Compared to Procaine Amide in the Normal and Digitalis‐Intoxicated Heart},
  author={R. Helfant and B. Scherlag and A. Damato},
  journal={Circulation},
  year={1967},
  volume={36},
  pages={108–118}
}
The effects of diphenylhydantoin sodium (Dilantin) on ventricular automaticity, intraventricular conduction, atrioventricular (A-V) conduction, and sinus rate have been determined in the digitalis-intoxicated and normal heart. These effects have been compared with procaine amide. Diphenylhydantoin sodium depresses ventricular automaticity and enhances A-V conduction while having little or no effect on intraventricular conduction or sinus rate. Procaine amide differed from diphenylhydantoin… Expand
Use of diphenylhydantoin sodium to dissociate the effects of procainamide on automaticity and conduction in the normal and arrhythmic heart.
TLDR
Findings have possible clinical significance, since ventricular arrhythmias caused by either enhanced automaticity or re-entry could be corrected by diphenylhydantoin in cases in which procainamide either does not correct or worsens the arrhythmia because of excessive conduction prolongation. Expand
The contrasting effects of diphenylhydantoin and procaine amide on A-V conduction in the digitalis-intoxicated and the normal heart.
TLDR
The selective effects of DPH are in contrast with agents such as procaine amide which depress both ventricular ectopia as well as A-V transmission in the digitoxic heart, however, DPH is contra-indicated in complete heart block. Expand
Effects of Diphenylhydantoin on Atrioventricular Conduction in Man
TLDR
Diphenylhydantoin-induced depression of the ventricular rate in atrial flutter or fibrillation may also be useful clinically, however, since diphenylHydantoin markedly decreases ventricular automaticity, its use in patients with complete heart block is contraindicated. Expand
Case Studies: Effect of Diphenylhydantoin on Induced Aberrant Conduction
TLDR
It is suggested that the present concept that DPH does not affect intraventricular conduction in man needs further evaluation. Expand
Serum levels and electrophysiological effects of N-acetlyprocainamide as compared with procainamide in the dog heart in situ.
The electrophysiological effects of procainamide and its major metabolite N-acetylprocainamide were tested and compared on the heart of the anaesthetized dog by means of His bundle electrography andExpand
Correlation of Antiarrhythmic Effects of Diphenylhydantoin with Digoxin‐Induced Changes in Myocardial Contractility, Sodium‐Potassium Adenosine Triphosphatase Activity, and Potassium Efflux
TLDR
The findings suggest that the antiarrhythmic effects of DPH cannot be attributed solely to prevention of inhibition of Na+-K+ ATPase activity or to diminution of K + efflux, two changes characteristically accompanying digoxin administration. Expand
Effects of Diphenylhydantoin on Excitability and Automaticity in the Canine Heart
TLDR
DPH decreased automaticity in the His-Purkinje system, evidenced by an increase in the ventricular escape time both during vagal stimulation in intact dogs and after ventricular overdrive in dogs with heart block. Expand
Electrophysiological Effects of Direct Current Countershock before and after Ouabain Sensitization and after Diphenylhydantoin Desensitization in the Dog
The effects of synchronized direct current countershock on ventricular automaticity, intraventricular conduction, and atrioventricular conduction were studied before and after ouabain administrationExpand
Diphenylhydantoin: pharmacological and clinical use.
  • A. Damato
  • Medicine
  • Progress in cardiovascular diseases
  • 1969
TLDR
DPH appears to have special utility in the treatment of ventricular arrhythmias, especially those which are digitalis-induced, and is effective when given prophylactically in clinical situations which predispose to the production of cardiac arrh rhythms. Expand
The effects of diphenylhydantoin on mechanical and electrical properties of isolated cat myocardium
TLDR
It is speculated that DPH leads to an accumulation of Ca2+ within a “limited subsarcolemmal space” thereby decreasing the driving force for the slow inward current. Expand
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