The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

  title={The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling},
  author={Thierry Virolle and E. D. Adamson and V{\'e}ronique T Baron and Diana Birle and Dan Mercola and Tomas M. Mustelin and Ian de Belle},
  journal={Nature Cell Biology},
The PTEN tumour suppressor and pro-apoptotic gene is frequently mutated in human cancers. We show that PTEN transcription is upregulated by Egr-1 after irradiation in wild-type, but not egr-1−/−, mice in vivo. We found that Egr-1 specifically binds to the PTEN 5′ untranslated region, which contains a functional GCGGCGGCG Egr-1-binding site. Inducing Egr-1 by exposing cells to ultraviolet light upregulates expression of PTEN messenger RNA and protein, and leads to apoptosis. egr-1−/− cells… CONTINUE READING
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ACKNOWLEDGEMENTS We are indebted to A. Krones for her skilled assistance in providing mutant and wild-type mouse tissues

  • G. J. Todaro, H. Green
  • J. Cell Biol
  • 1963

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