The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

@article{Virolle2001TheET,
  title={The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling},
  author={Thierry Virolle and E. D. Adamson and V{\'e}ronique T Baron and Diana Birle and Dan Mercola and Tomas M. Mustelin and Ian de Belle},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={1124-1128}
}
The PTEN tumour suppressor and pro-apoptotic gene is frequently mutated in human cancers. We show that PTEN transcription is upregulated by Egr-1 after irradiation in wild-type, but not egr-1−/−, mice in vivo. We found that Egr-1 specifically binds to the PTEN 5′ untranslated region, which contains a functional GCGGCGGCG Egr-1-binding site. Inducing Egr-1 by exposing cells to ultraviolet light upregulates expression of PTEN messenger RNA and protein, and leads to apoptosis. egr-1−/− cells… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
159 Extracted Citations
1 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 159 extracted citations

Referenced Papers

Publications referenced by this paper.

ACKNOWLEDGEMENTS We are indebted to A. Krones for her skilled assistance in providing mutant and wild-type mouse tissues

  • G. J. Todaro, H. Green
  • J. Cell Biol
  • 1963

Similar Papers

Loading similar papers…