Corpus ID: 74520380

The Efficacy of Topical Glucosamine Sulfate-Chondroitin Sulfate in Knee Osteoarthritis Treated With Physical Therapy: A Randomized, Double-Blind, Placebo-Controlled Study Fizik Tedavi Uygulanan Diz Osteoartritli Hastalarda Topikal Glukozamin Sülfat-Kondroitin Sülfatin Etkinliği: Randomize Çift Kör P

@inproceedings{Erhan2012TheEO,
  title={The Efficacy of Topical Glucosamine Sulfate-Chondroitin Sulfate in Knee Osteoarthritis Treated With Physical Therapy: A Randomized, Double-Blind, Placebo-Controlled Study Fizik Tedavi Uygulanan Diz Osteoartritli Hastalarda Topikal Glukozamin S{\"u}lfat-Kondroitin S{\"u}lfatin Etkinliği: Randomize Çift K{\"o}r P},
  author={B. Erhan and B. G{\"u}nd{\"u}z and G{\"u}ls{\"u}n Iska and Zuhal Karakoyun},
  year={2012}
}

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Topical Therapies for Osteoarthritis
TLDR
Topical NSAIDs have been available in Europe for decades and were introduced to provide localized analgesia with minimal systemic NSAID exposure, but neither has shown substantial efficacy in clinical trials, and both have potential to cause serious AEs. Expand
OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines.
TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis. Expand
The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial.
TLDR
At 2 years, no treatment achieved a predefined threshold of clinically important difference in JSW loss as compared with placebo, however, knees with K/L grade 2 radiographic OA appeared to have the greatest potential for modification by these treatments. Expand
Glucosamine and Chondroitin Sulfate as Therapeutic Agents for Knee and Hip Osteoarthritis
TLDR
Glucosamine sulfate (but not glucosamine hydrochloride) and chondroitin sulfate have small-to-moderate symptomatic efficacy in OA, although this is still debated. Expand
A history of the understanding of cartilage.
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TLDR
The history of research on hyaline cartilage illustrates the dependence of scientific progress on technologic innovation. Expand
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
TLDR
Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain, and the efficacy and safety of these treatments as a treatment for knee pain from osteoarthritis are evaluated. Expand
Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness.
TLDR
This maximum concentration of 11.5 micromol/l has previously been shown to contribute less than 2% of the galactosamine incorporated into chondroitin sulphate in incubations of glucosamine with cultured human chondrocytes, and is a much lower concentration than the glucosamines claimed by other investigators to have various significant in vitro effects. Expand
A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee.
TLDR
Topical application of glucosamine and chondroitin sulfate is effective in relieving the pain from OA of the knee and improvement is evident within 4 weeks. Expand
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TLDR
The updated EULAR recommendations support some of the previous propositions published in 2000 but also include modified statements and new propositions. Expand
Prevalence of rheumatic diseases in a rheumatological outpatient practice
TLDR
Soft tissue rheumatism and degenerative joint and spine diseases are the most common rheumatological diagnoses in newly referred patients visiting a community based rheumatic outpatient practice. Expand
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