The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia

@article{Large2011TheEO,
  title={The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia},
  author={Charles H. Large and Silvia Bison and I. Sartori and Kevin D. Read and Alessandro Gozzi and Davide Quarta and Marinella Antolini and Emma C Hollands and Catherine H. Gill and Martin J. Gunthorpe and Nagi F. Idris and Joanna C. Neill and Giuseppe S. Alvaro},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2011},
  volume={338},
  pages={100 - 113}
}
Sodium channel inhibition is a well precedented mechanism used to treat epilepsy and other hyperexcitability disorders. The established sodium channel blocker and broad-spectrum anticonvulsant lamotrigine is also effective in the treatment of bipolar disorder and has been evaluated in patients with schizophrenia. Double-blind placebo-controlled clinical trials found that the drug has potential to reduce cognitive symptoms of the disorder. However, because of compound-related side-effects and… Expand
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