The Efficacy of Prostaglandin E1 Derivative in Patients With Lumbar Spinal Stenosis

@article{Matsudaira2009TheEO,
  title={The Efficacy of Prostaglandin E1 Derivative in Patients With Lumbar Spinal Stenosis},
  author={Ko Matsudaira and Atsushi Seichi and Junichi Kunogi and Takashi Yamazaki and Atsuki Kobayashi and Yorito Anamizu and Junji Kishimoto and Kazuto Hoshi and Katsushi Takeshita and Kozo Nakamura},
  journal={Spine},
  year={2009},
  volume={34},
  pages={115-120}
}
Study Design. Randomized controlled trial. Objective. To examine the effect of limaprost, an oral prostaglandin (PG) E1 derivative, on health-related quality of life (HRQOL) in patients with symptomatic lumbar spinal stenosis (LSS), compared to etodolac, a NSAID. Summary of Background Data. Limaprost, an oral PGE1 derivative, was developed in Japan to treat numerous ischemic symptoms of thromboangiitis obliterans (TAO) and LSS. Previous studies have demonstrated the effectiveness of limaprost… 
The effect of a prostaglandin E1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis
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TLDR
Prostaglandin E1 analogs may provide benefit as a conservative treatment option for patients with lumbar spinal stenosis, however, higher-quality studies conducted in the United States and comparison with other currently used conservative treatments are required before it can be recommended for routine clinical use.
Nonoperative Treatment of Lumbar Spinal Stenosis With Neurogenic Claudication: A Systematic Review
TLDR
Moderate- and high-GRADE evidence for nonoperative treatment is lacking and thus prohibiting recommendations to guide clinical practice, given the expected exponential rise in the prevalence of lumbar spinal stenosis with neurogenic claudication.
Prostaglandin E1 Treatment for Lumbar Spinal Canal Stenosis: Review of the Literature
  • H. Yoshihara
  • Medicine
    Pain practice : the official journal of World Institute of Pain
  • 2016
TLDR
Prostaglandin E1 presumably improves symptoms in patients with LSCS by improving the blood flow in the cauda equina and nerve roots through its vasodilation and antiplatelet aggregation effects.
Neurogenic Claudication: a Review of Current Understanding and Treatment Options
TLDR
It is found that there continues to be a lack of consensus on the diagnostic criteria, management, and treatment options for patients with LSS and there is not enough high-quality evidence to make a recommendation regarding the use of MILD versus interspinous spacers for neurogenic claudication.
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