The Efficacy of Curcumin on Cognition, Depression, and Agitation in Older Adults with Alzheimer’s Disease

  title={The Efficacy of Curcumin on Cognition, Depression, and Agitation in Older Adults with Alzheimer’s Disease},
  author={Jyotsna Sharman and Roofia Galeshi and Lisa L. Onega and Susanne Ashby and Kavya Sharman},
  journal={The Open Nutrition Journal},
The purpose of this systematic review was to ascertain the current state of science regarding the use of turmeric and its pigment curcumin in individuals with Alzheimer’s Disease (AD). A summary of qualitative and quantitative evidence specific to the effect of curcumin on AD is presented in this article. The purpose of the review was to evaluate and summarize findings related to this body of research. Findings indicated a positive correlation between administration of turmeric and improvement… Expand
3 Citations
Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: a systematic review and dose-response meta-analysis of randomized controlled trials.
The significant positive impact of curcumin supplementation on BDNF levels indicates its potential use for neurological disorders that are associated with lowBDNF levels. Expand
Trans-cinnamaldehyde Modulates Hippocampal Nrf2 Factor and Inhibits Amyloid Beta Aggregation in LPS-Induced Neuroinflammation Mouse Model
CNM produces its memory enhancing effects through modulation of Nrf2 antioxidant defense in hippocampus, inhibition of neuroinflammation, apoptosis and amyloid protein burden. Expand
CurQfen ® Turmeric + Fenugreek
  • 2019
INGREDIENTS Doctor’s Best Turmeric Plus Fenugreek with CurQfen® features a bioenhanced formulation of curcumin using fenugreek-derived soluble dietary fiber. It is a 100% natural food-gradeExpand


Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
Chronic supplementation with curcumin produced significant antidepressant behavioral response in depressed patients by reduction of 17-item Hamilton Depression Rating Scale and Montgomery-Asberg depression Rating Scale scores. Expand
Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia
Three patients with the Alzheimer's Disease whose behavioral symptoms were improved remarkably as a result of the turmeric treatment, which is the traditional Indian medicine are described, leading to probable benefit of the use of turmeric in individuals with the AD with BPSD. Expand
The effect of curcumin (turmeric) on Alzheimer's disease: An overview
Due to various effects of curcumin, such as decreased Beta-amyloid plaques, delayed degradation of neurons, metal-chelation, anti-inflammatory, antioxidant and decreased microglia formation, the overall memory in patients with AD has improved. Expand
Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study.
Partial support is provided for the antidepressant effects of curcumin in people with major depressive disorder, evidenced by benefits occurring 4 to 8 weeks after treatment. Expand
Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
Curcumin was generally well-tolerated although three subjects on curcumin withdrew due to gastrointestinal symptoms, and preliminary data suggest limited bioavailability of this compound. Expand
Curry consumption and cognitive function in the elderly.
Tentative evidence of better cognitive performance from curry consumption in nondemented elderly Asians is reported, which should be confirmed in future studies. Expand
Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial
This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD without concurrent suicidal ideation or other psychotic disorders. Expand
A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers
The complexities associated with biomarker assessment are reviewed specifically around their collection, analysis and interpretation and focus is placed on the potential of peripheral biomarkers to aid diagnosis, predict treatment response, enhance treatment-matching and prevent the onset or relapse of major depression. Expand
Incidence of Alzheimer’s disease in a rural community in India
These are the first AD incidence rates to be reported from the Indian subcontinent, and they appear to be among the lowest ever reported, however, the relatively short duration of follow-up, cultural factors, and other potential confounders suggest caution in interpreting this finding. Expand
Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients.
Immunomodulation of the innate immune system by curcuminoids might be a safe approach to immune clearance of amyloidosis in AD brain. Expand