The Efficacy of CD 3 x CD 19 Bispecific Monoclonal Antibody ( BsAb ) in a Clonogenic Assay : The Effect of Repeated Addition of BsAb and Interleukin-2

@inproceedings{Geerars2000TheEO,
  title={The Efficacy of CD 3 x CD 19 Bispecific Monoclonal Antibody ( BsAb ) in a Clonogenic Assay : The Effect of Repeated Addition of BsAb and Interleukin-2},
  author={Anette J. G. Geerars and B. M. de and Bert E. J. E. G. Bast and Bert and de Gast},
  year={2000}
}
To evaluate the potency by which human T cells are targeted and activated by bispecific monoclonal antibodies (BsAbs) t o lyse tumor cells, a clonogenic assay was developed. The efficacy of a CD3xCD19 BsAb binding to both the CD3 T-cell antigen and the CD19 B-cell antigen was already proven in "Cr-release assays and in 3-day activation cultures. To achieve more quantitative results, a 14-day clonogenic assay, based on limiting-dilution, was performed for the determination of the initial and… CONTINUE READING
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Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 24 references

The spearman estimator for serial dilution assays

  • EA Johnson, BW Brown
  • Cancer lmmunol Immunother
  • 1994

Interaction of human monocyte Fcy receptors with rat IgG 2 b : A new indicator for the FcyRIla ( RH 131 ) polymorphism

  • Haagen l-A, Geerars AJG, MR Clark, van de Winkel JGJ
  • Cancer Immunol Immu - nother
  • 1992

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